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Vaccines & Infectious Diseases

“To combat infectious diseases, such as COVID-19 and influenza, 我们正在全面评估目前使用的疫苗的安全性和有效性, conducting clinical trials of promising new vaccines, and studying the patterns of how these illnesses spread.”

Lisa A. Jackson, MD, MPH
凯撒永久华盛顿健康利记官网所高级利记官网

Research overview

疫苗通过保护人们免受传染病——脊髓灰质炎——的侵害来挽救生命, influenza, and pneumonia to name a few. 凯撒永久医疗机构华盛顿健康利记官网所(利记官网 Washington Health Research Institute, 利记官网)正在努力通过不断提高对公共卫生具有重要意义的传染病疫苗的安全性和有效性的利记官网来保护社区.

这项工作的核心是测试针对COVID-19等新出现疾病的新疫苗. In March 2020, 利记官网 gave the world’s first-ever injection 在高级利记官网员的领导下,一种新型冠状病毒疫苗正在进行1期临床试验 Lisa A. Jackson, MD, MPH. 我们将继续站在了解和抗击COVID-19的最前沿. To learn more, see COVID-19 research at 利记官网.

利记官网所30多年来疫苗利记官网取得的成就包括:

  • 一项针对老年人接种流感疫苗的大型利记官网发现,疫苗可能无法像希望的那样保护他们免受肺炎的侵害
  • 对全国老年人带状疱疹疫苗安全性的“实时”评估 Vaccine Safety Datalink network
  • 利记官网性流感疫苗的临床试验,包括针对大流行性流感和流感的疫苗 bird flu, in adults
  • Studies to better understand and address vaccine hesitancy 在那些因为担心安全而推迟或拒绝给孩子接种疫苗的家庭中, 导致百日咳和麻疹等潜在致命疾病的爆发
  • 成人肺炎球菌多糖疫苗有效性的最大回顾性利记官网, 也是该疫苗安全性的最大临床试验
  • The pivotal clinical trials of 7-valent, 13-valent, 老年人使用20价肺炎球菌结合疫苗 

我们目前关于疫苗和传染病的利记官网项目包括:

  • 疫苗和治疗评价股进行的临床试验, 由国家过敏和传染病利记官网所资助, 也是传染病临床利记官网联盟(IDCRC)的成员. Led by Dr. Lisa Jackson, the unit launched the world’s first trial of an experimental COVID-19 vaccine — the now-approved NIH-Moderna vaccine ——并继续测试COVID-19疫苗和增强剂的安全性和有效性. To learn more, see COVID-19 research at 利记官网.
  • 利记官网COVID-19和流感等传染病如何在社区传播
  • 开展利记官网,探索哪种类型的沟通和社区参与战略最有效地提高长期护理机构工作人员的COVID-19疫苗吸收率. Clarissa Hsu, PhD他领导了这项利记官网,该利记官网由美国联邦政府资助.由以患者为中心的结果利记官网所(PCORI).
  • 美国正在对流感和COVID-19疫苗的有效性进行持续监测.S. Influenza Vaccine Effectiveness Network, led by Karen J. Wernli, PhD, 利记官网高级利记官网员,由疾病控制和预防中心资助。
  • Studies of immunization safety through the Vaccine Safety Datalink project, 由疾病预防控制中心支持,并将包括华盛顿凯撒医疗机构在内的8个美国健康计划维护的大型数据库中的信息连接起来
  • Methodological research, led by Jennifer C Nelson, PhD, and Andrea J. Cook, PhD, 改进用于解决电子健康记录数据设置中疫苗安全问题的统计设计和分析方法

Recent publications on Vaccines & Infectious Disease

Bi Q, Dickerman BA, Nguyen HQ, Martin ET, Gaglani M, Wernli KJ, Balasubramani GK, Flannery B, Lipsitch M, Cobey S; US Flu Vaccine Effectiveness Network Investigators. 重复接种流感疫苗的有效性降低:季节内减弱的区别, recent clinical infection, and subclinical infection. J Infect Dis. 2024 Apr 30:jiae220. doi: 10.1093/infdis/jiae220. Online ahead of print. PubMed

Daley MF, Reifler LM, Shoup JA, Glanz JM, Lewin BJ, Klein NP, Kharbanda EO, McLean HQ, Hambidge SJ, Nelson JC, Naleway AL, Weintraub ES, McNeil MM, Razzaghi H, Singleton JA. 成人流感疫苗接种的准确性:自我报告与电子健康记录数据的比较.  Vaccine. 2024;42(11):2740-2746. doi: 10.1016/j.vaccine.2024.03.052. Epub 2024 Mar 25. PubMed

Magaret C, Li L, deCamp A, Rolland M, Juraska M, Williamson B, Ludwig J, Molitor C, Benkeser D, Luedtke A, Simpkins B, Carpp L, Bai H, Deariove B, Greninger A, Roychoudhury P, Sadoff J, Gray G, Roels S, Vandebosch A, Stieh D, Le Gars M, Vingerhoets J, Grinsztejn B, Goepfert P, Truyers C, Van Dromme I, Swann E, Marovich M, Follmann D, Neuzil K, Corey L, Hyrien O, Paiva de Sousa L, Casapia M, Losso M, Little S, Gaur A, Bekker LG, Garrett N, Heng F, Sun Y, Gilbert P. Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features.  Nat Commun. 2024;15(1):2175. doi: 10.1038/s41467-024-46536-w.  PubMed

Frutos AM, Price AM, Harker E, Reeves EL, Ahmad HM, Murugan V, Martin ET, House S, Saade EA, Zimmerman RK, Gaglani M, Wernli KJ, Walter EB, Michaels MG, Staat MA, Weinberg GA, Selvarangan R, Boom JA, Klein EJ, Halasa NB, Ginde AA, Gibbs KW, Zhu Y, Self WH, Tartof SY, Klein NP, Dascomb K, DeSilva MB, Weber ZA, Yang DH, Ball SW, Surie D, DeCuir J, Dawood FS, Moline HL, Toepfer AP, Clopper BR, Link-Gelles R, Payne AB, Chung JR, Flannery B, Lewis NM, Olson SM, Adams K, Tenforde MW, Garg S, Grohskopf LA, Reed C, Ellington S; CDC Influenza Vaccine Effectiveness Collaborators. 2023- 2024年季节性流感疫苗有效性的中期估计——美国. MMWR Morb Mortal Wkly Rep. 2024;73(8):168-174. doi: 10.15585/mmwr.mm7308a3.  PubMed

Sumner KM, Yadav R, Noble EK, Sandford R, Joshi D, Tartof SY, Wernli KJ, Martin ET, Gaglani M, Zimmerman RK, Talbot HK, Grijalva CG, Belongia EA, Chung JR, Rogier E, Coughlin MM, Flannery B. 门诊接受SARS-CoV-2检测的患者抗SARS-CoV-2抗体水平与COVID-19保护相关, US Flu VE Network, October 2021-June 2022. J Infect Dis. 2024 Feb 23:jiae090. doi: 10.1093/infdis/jiae090. [Epub ahead of print]. PubMed

Researchers in Vaccines & Infectious Disease

Lisa A. Jackson, MD, MPH

Senior Investigator
Lisa.A.Jackson@kp.org

Curriculum vitae (CV)

Jennifer C. Nelson, PhD

Director, Biostatistics; Senior Investigator
206-287-2004
Jen.Nelson@kp.org

Curriculum vitae (CV)

Andrea J. Cook, PhD

Senior Biostatistics Investigator
206-287-4257
Andrea.J.Cook@kp.org

Curriculum vitae (CV)

Sascha Dublin, MD, PhD

Senior Investigator
206-287-2870
Sascha.Dublin@kp.org

Curriculum vitae (CV)

Onchee Yu, MS

Principal Collaborative Biostatistician
206-287-2389
Onchee.Yu@kp.org

Curriculum vitae (CV)

Robert D. Wellman, MS

Principal Collaborative Biostatistician
206-287-2557
Robert.D.Wellman@kp.org

Curriculum vitae (CV)

Clarissa Hsu, PhD

Associate Investigator
206-287-4276
Clarissa.W.Hsu@kp.org

Curriculum vitae (CV)

Brian D. Williamson, PhD

Assistant Biostatistics Investigator
206-287-2024
Brian.D.Williamson@kp.org

Curriculum vitae (CV)

Noorie Hyun, PhD

Associate Biostatistics Investigator
Noorie.Hyun@kp.org

Curriculum vitae (CV)

Pamela A. Shaw, PhD, MS

Senior Biostatistics Investigator
Pamela.A.Shaw@kp.org

Curriculum vitae (CV)

Annie Piccorelli, PhD

Senior Collaborative Biostatistician
Annie.V.Piccorelli@kp.org

Curriculum vitae (CV)

 

Affiliate researchers

Doug Opel, MD, MPH
University of Washington (UW) Department of Bioethics and Humanities; UW Department of Pediatrics; UW Medical Center

Adjunct researchers

John Dunn, MD, MPH
Kaiser Foundation Health Plan of Washington

Elizabeth Lin, MD, MPH
凯撒基金会华盛顿家庭诊所健康计划;
利记官网 Washington Health Research Institute